Mafia is renowned as an excellent world-class diving destination with some of the richest reefs in the world, The park covers the Southern part of Mafia Island and includes the inhabited islands of Chole, Juani Jibondo and Bwejuu and several uninhabited islets and the associated waters.
Mafia Island and its chain of small islets lie approximately 120 km south of Dar es Salaam and 20 km offshore from the eastern extent of the Rufiji is one of the largest delta systems in Africa. To the east of Mafia Island is the Indian Ocean. The main island of Mafia is about 48 km long and 17 km wide at its widest point. Several smaller islands and islets are scattered to the west and south.